کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2538153 1559636 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neuroprotective and antioxidant lanostanoid triterpenes from the fruiting bodies of Ganoderma atrum
ترجمه فارسی عنوان
سه terpenes lanostanoid حفاظت عصبی و آنتی اکسیدان از fruiting bodies atrum گانودرما
کلمات کلیدی
Ganoderma atrum؛ Ganodermataceae؛ لانواستانوئید triterpenes؛ فعالیت حفاظت عصبی؛ فعالیت آنتی اکسیدانی
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
چکیده انگلیسی

Five new lanostanoid triterpenes were isolated from the ethanol extract of the fruiting bodies of Ganoderma atrum. The structures of the isolated compounds were established based on 1D and 2D (1H–1H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated compounds were tested in vitro for neuroprotective activities against 6-OHDA-induced cell death in SH-SY5Y cells and radical scavenging activities. As a result, compounds 2 and 5 exhibited potent neuroprotective activity against 6-OHDA-induced cell death in SH-SY5Y cells with the lowest IC50 value (0.5 μM) while compounds 1, 3 and 4 possessed significant neuroprotective activity with IC50 value less than 10 μM. Additionally, all tested compounds 1–6 showed the comparable free radical scavenging activities with the standard drug trolox in both ABTS + and DPPH experiment.

Neuroprotective and antioxidant lanostanoid triterpenes from the fruiting bodies of G. atrum.Figure optionsDownload high-quality image (287 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 109, March 2016, Pages 75–79
نویسندگان
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