Leucocontextins A–R, lanostane-type triterpenoids from Ganoderma leucocontextum

Eighteen new lanostane-type triterpenoids, namely leucocontextins A–R (1–18) were isolated from the fruiting bodies of Ganoderma leucocontextum. Their structures were established by 1D and 2D NMR data in conjunction with HRESIMS/HREIMS, X-ray single crystal diffraction analysis. Compound 18 exhibited weak cytotoxicity against K562 and MCF-7 cell lines with IC50 of 20–30 μM.

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