Pterocarpans and triterpenoids from Gueldenstaedtia verna

Two new pterocarpan glycosides (1–2), five new triterpenoids (3–7), and 13 known analogues (14–20) were isolated from the whole plants of Gueldenstaedtia verna. These new compounds (1–7) were elucidated by extensive spectroscopic techniques including 1D (1H and 13C) and 2D NMR experiments (COSY, HSQC, HMBC and NOESY), HR-ESI-MS and chemical methods. The absolute configuration of 1 was established by the optical rotation, the comparison of experimental and calculated electronic circular dichroism (ECD) spectra and an X-ray diffraction analysis. All the isolates were evaluated for their cytotoxicities against four human cancer cell lines and inhibitory activities on LPS-induced NO production in RAW264.7 cells.

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