Three new 1α-alkyldaphnane-type diterpenoids from the flower buds of Wikstroemia chamaedaphne

Three new 1α-alkyldaphnane type diterpenoids, wikstroelides R–T (1–3), together with three known analogs, genkwadane C (4), pimelea factors S6 (5) and S7 (6), two known 1α-alkyldaphnane ketal-lactone type diterpenoids, pimelotides A (7) and C (8), and a known daphnane type diterpenoid, simplexin (9), were isolated from the flower buds of Wikstroemia chamaedaphne. Their structures were elucidated by a combination of spectroscopic analyses including HRESIMS and NMR. Compounds 1–9 were evaluated for their cytotoxic activities in vitro, and most of them exhibited moderate cytotoxic activities with IC50 values ranging from 8.7–22.0 μM.

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