New triterpenoids from the latex of Euphorbia resinifera Berg.

Nine novel compounds, six euphane triterpenes, Euphorol A–D (1–4), H (8) and I (9), and three tirucallane triterpenes, Euphorol E–G (5–7) including four nortriterpenes, together with seven known compounds (10–16) have been isolated from the methanol extraction of Euphorbium. Their structures were established on the basis of extensive analyses of their HR-ESI-MS, UV, IR, 1D and 2D NMR methods. A putative biogenetic relationship to these compounds was proposed. The cytotoxicity of all these isolates against MCF-7, U937 and C6 cancer cell lines was evaluated. Compounds 1–3, 10, 11 and 13–16 exhibited moderate cytotoxic activities.

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