Anti-cancer agents derived from solid-state fermented Antrodia camphorata mycelium

Three new ubiquinone derivatives, antrocamol LT1, antrocamol LT2, and antrocamol LT3, along with two known compounds, were isolated from Antrodia camphorata (Polyporaceae) mycelium. The structures of these compounds were established on the basis of extensive 1D and 2D NMR spectroscopic analyses. These ubiquinones exhibited selective cytotoxicities against five human cancer cell lines (CT26, A549, HepG2, PC3 and DU-145) with IC50 values ranging from 0.01 to 1.79 μΜ.

Three new ubiquinone derivatives, antrocamol LT1, LT2 and LT3, were isolated from Antrodia camphorate mycelium and exhibited potential cytotoxicities against five human cancer cell lines.Figure optionsDownload high-quality image (111 K)Download as PowerPoint slide