Kaennacowanols A–C, three new xanthones and their cytotoxicity from the roots of Garcinia cowa

Three new xanthones, named kaennacowanols A–C (1–3), along with nineteen known xanthones were isolated from the roots of Garcinia cowa Roxb. Their structures were determined by spectroscopic analysis. All isolated compounds were evaluated for their cytotoxicity against KB and HeLa cell lines. Compounds 17 and 22 showed good cytotoxicity against KB cell with IC50 values of 7.97 and 9.10 μM, respectively. On the other hand, compound 15 showed good cytotoxicity against HeLa cell with IC50 value of 9.34 μM.

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