کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2538335 | 1559642 | 2015 | 6 صفحه PDF | دانلود رایگان |
Five new benzylphenanthrenes, cremaphenanthrenes L–P (1–5) were isolated from the EtOAc-soluble extract of the tubers of Cremastra appendiculata. Their structures were elucidated based on the spectroscopic data and chemical methods. Compounds 1–5 were tested in vitro for their cytotoxic effects against colon (HCT-116), cervix (Hela), and breast (MCF-7 and MDA-MB-231) cancer cell lines. Compound 1 showed moderate cytotoxic activities against HCT-116, MCF-7, and MDA-MB-231 cancer cell lines with IC50 values ranging from 15.84 to 24.18 μM and weak cytotoxicity to Hela cell line with IC50 value of 68.81 μM.
Graphic abstractPhytochemical investigation has led to the isolation of five new benzylphenanthrenes, cremaphenanthrenes L–P (1–5) from the tubers of Cremastra appendiculata. Compound 1 showed moderate cytotoxic activity against HCT-116, MCF-7, and MDA-MB-231 cancer cell lines with IC50 values ranging from 15.84 to 24.18 μM and weak cytotoxicity to Hela cell line with IC50 value of 68.81 μM.Figure optionsDownload high-quality image (131 K)Download as PowerPoint slide
Journal: Fitoterapia - Volume 103, June 2015, Pages 27–32