کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2538465 1559646 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cytotoxic and anti–inflammatory tirucallane triterpenoids from Dysoxylum binectariferum
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Cytotoxic and anti–inflammatory tirucallane triterpenoids from Dysoxylum binectariferum
چکیده انگلیسی

Four new tirucallane triterpenoids 1–4 along with two known compounds 5 and 6 were isolated from the stem bark of Dysoxylum binectariferum. Their structures were elucidated on the basis of extensive 1D and 2D NMR (COSY, HMQC, HMBC and NOESY) analyses. The isolated compounds were evaluated in vitro for anti-inflammatory and cytotoxic potential against eight tumor cell lines. Compounds 1–6 exhibited significant selective inhibition of Cox-1 and selectively significant cytotoxic against five tumor cell lines (A-549, HCT15, HepG2, SGC-7901 and SK-MEL-2), especially against HepG2 cell lines with IC50 value of 7.5–9.5 μM.

Cytotoxic and anti-inflammatory tirucallane triterpenoids 1–6 were isolated from the stem bark of Dysoxylum binectariferum.Figure optionsDownload high-quality image (166 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 99, December 2014, Pages 86–91
نویسندگان
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