کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2538466 | 1559646 | 2014 | 7 صفحه PDF | دانلود رایگان |

Four new neolignans, meliasendanins A–D (1–4), and a new glycoside, toosenoside A (5), together with ten known ones (6–15), were isolated from a n-BuOH partition of the fruits of Melia toosendan. Their structures were elucidated by analyses of extensive spectroscopic data and comparison of the NMR data with those reported previously. Meliasendanin A (1) was a rare neolignan containing isochroman moiety, and its absolute configuration was determined using a CD spectrum. Toosenoside A (5) was an unusual glycoside with a rare naturally occurring aglycone and its structure was confirmed by X-ray single crystal diffraction analysis. The antioxidant activity of the isolated neolignans and lignans was evaluated by ABTS radical-scavenging assay. Compounds 1 and 13 exhibited strong antioxidant activity, with IC50 values of 62.8 and 45.1 μM, respectively.
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Journal: Fitoterapia - Volume 99, December 2014, Pages 92–98