کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2538509 1559647 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cytotoxic eburnamine-aspidospermine type bisindole alkaloids from Bousigonia mekongensis
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Cytotoxic eburnamine-aspidospermine type bisindole alkaloids from Bousigonia mekongensis
چکیده انگلیسی

Four new eburnamine-aspidospermine type bisindole alkaloids, namely, mekongenines C–F (1–4), along with 27 known indole alkaloids were isolated from the twigs and leaves of Bousigonia mekongensis. Their structures with the absolute configurations were elucidated by spectroscopic methods and ECD analyses. All new compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Alkaloids 1–4 exhibited inhibitory effects with IC50 values comparable to those of cisplatin.

Four new eburnamine-aspidospermine type bisindole alkaloids, namely, mekongenines C–F (1–4), along with 27 known indole alkaloids were isolated from the twigs and leaves of Bousigonia mekongensis. Their structures with the absolute configurations were elucidated by spectroscopic method and ECD analysis. All new compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Alkaloids 1–4 exhibited inhibitory effects with IC50 values comparable to those of cisplatin.Figure optionsDownload high-quality image (279 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 98, October 2014, Pages 45–52
نویسندگان
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