کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2538522 1559647 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Triterpenoids of sour jujube show pronounced inhibitory effect on human tumor cells and antioxidant activity
ترجمه فارسی عنوان
تریترپروئید های جویبار ترش نشان دهنده اثر مهاری بر روی سلول های توموری انسان و فعالیت آنتیاکسیدانی
کلمات کلیدی
یخ زده یخ زده تریترپروئید، شناسایی ساختار، فعالیت ضد انعقادی، فعالیت آنتیاکسیدانی
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
چکیده انگلیسی

Sour jujube is a common fruit and traditional medicine in China. Bioactivity-guided fractionation of sour jujube was used to determine the chemical identity of potent antiproliferative and antioxidant constituents. Four novel ursane-type triterpenoids, together with 8 known were isolated and identified. The new triterpenoids were elucidated to be 2α,3β,13β,23-tetrahydroxy-urs-11-en-28-oic acid (3), 2α,3β-dihydroxy-urs-20(30)-en-28-oic acid (9), 2α,3β,28-trihydroxy-urs-20(30)-ene (10), and 3β,12β,13β-trihydroxy-ursan-28-oic acid (11). Among the triterpenoids isolated, 2α,3β,19α-trihydroxy-urs-12-en-28-oic acid (7), 9 and 10 showed high potent inhibitory activity toward the proliferation of HepG2 cells, which the IC50 values were lower than 5 μM. Compounds 9 and 10 also exhibited pronounced activity against MCF-7 cells, with IC50 value of 0.8 ± 0.03 and 1.5 ± 0.1 μM, respectively. Compound 10 showed high antioxidant activity with an EC50 of 0.8 ± 0.02 μM, which was 18.9 times higher than ascorbic acid in antioxidant capacity.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 98, October 2014, Pages 137–142
نویسندگان
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