Anti-inflammatory and cytotoxic 2-arylbenzofurans from Morus wittiorum

Three new 2-arylbenzofurans named wittifuran H, wittifuran I and wittifuran U (1–3) were obtained during our ongoing investigation of an ethanol extract from the stem bark of Morus wittiorum. Their structures were elucidated on the basis of spectroscopic data. Compound 2 displayed potent anti-inflammatory activity and selective cytotoxicity against human gastric cancer cell line BGC-823 with an IC50 value of 1.45 μM.

Three new 2-arylbenzofurans named wittifuran H, wittifuran I and wittifuran U (1–3) were obtained from the stem bark of Morus wittiorum. Compound 2 displayed potent anti-inflammatory activity and selective cytotoxicity against human gastric cancer cell line BGC-823 with an IC50 value of 1.45 μM.Figure optionsDownload high-quality image (45 K)Download as PowerPoint slide