کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2538799 1122154 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cytotoxic triterpene saponins from the leaves of Aralia elata
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Cytotoxic triterpene saponins from the leaves of Aralia elata
چکیده انگلیسی

Phytochemical investigation of the leaves of Aralia elata has led to the isolation of four new compounds, 3-O-β-d-glucopyranosyl (1 → 3)-β-d-glucopyranosyl (1 → 3)-β-d-glucopyranosyl oleanolic acid (1), 3-O-[β-d-glucopyranosyl (1 → 3)-β-d-glucopyranosyl (1 → 3)]-[β-d-glucopyranosyl (1 → 2)]-β-d-glucopyranosyl hederagenin 28-O-β-d-glucopyranoside (2), 3-O-{[β-d-glucopyranosyl (1 → 2)]-[β-d-glucopyranosyl (1 → 3)-β-d-glucopyranosyl (1 → 3)]-β-d-glucopyranosyl} oleanolic acid 28-O-β-d-glucopyranosyl ester (3) and 3-O-[β-d-glucopyranosyl (1 → 2)]-[β-d-glucopyranosyl (1 → 3)]-β-d-glucopyranosyl caulophyllogenin (4) and two known compounds, 3-O-[β-d-glucopyranosyl (1 → 3)-α-l-arabinopyranosyl]-echinocystic acid (5) and 3-O-α-l-arabinopyranosyl echinocystic acid (6). The structural determination was accomplished with spectroscopic analysis, in particular 13C-NMR, 2D-NMR and HR-ESI-MS techniques. Compounds 1–6 were tested for their inhibition of the growth of HL60, A549 and DU145 cancer cells. Compound 1 showed significant cytotoxic activity against HL60 and A549 cancer cells with IC50 values of 6.99 μM and 7.93 μM respectively. In addition, compounds 5 and 6 showed significant cytotoxic activity against HL60 cancer cells with IC50 values of 5.75 μM and 7.51 μM, respectively.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 83, Issue 4, June 2012, Pages 806–811
نویسندگان
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