کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2538893 | 1559660 | 2013 | 8 صفحه PDF | دانلود رایگان |

Five new saikosaponins, saikosaponin w (1), 21β-hydroxysaikosaponin b2 (2), 6″-O-acetylsaikosaponin e (3), 6″-O-acetylsaikosaponin b1 (4), and 6″-O-acetylsaikosaponin b3 (5), along with twenty-two known ones (6–27), have been isolated from the roots of Bupleurum chinense. Their structures were elucidated on the basis of detailed spectroscopic analysis, including mainly 1D and 2D NMR and HRESI-MS, qualitative chemical methods, and comparison with the literatures. Osteoclast-inhibiting activity of some of the isolated compounds was evaluated in vitro, with five ones have shown significant activity by inhibitory rates ranging from 48.3% to 56.1% at the concentration of 10 μM and with significant differences among groups observed.
Five new saikosaponins, along with twenty-two known ones, have been isolated and identified from the roots of Bupleurum chinense. Some of the isolated compounds showed osteoclast-inhibiting activity.Figure optionsDownload high-quality image (113 K)Download as PowerPoint slide
Journal: Fitoterapia - Volume 85, March 2013, Pages 101–108