کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2538921 1122159 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antioxidant flavanes from Livistona chinensis
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Antioxidant flavanes from Livistona chinensis
چکیده انگلیسی

Three new flavanes and eight known flavonoids were isolated from the fruits of Livistona chinensis. The structure of the new flavanes were established as 2S,3S-3,5,7,3′,5′-pentahydroxyflavane (1), 2R,3R-3,5,6,7,8,4′-hexahydroxyflavane (2) and 2R,3R-3,5,6,7,8,3′,5′-heptahydroxyflavane (3), respectively, on the basis of chemical and spectroscopic data. The antiproliferative activity against four human tumor cell lines (HL-60, Mata, HepG2 and CNE-1) was evaluated. 1 had significantly antiproliferative effects against HL-60 and CNE-1 with the IC50 of 0.2 ± 0.01 and 1.0 ± 0.1 μM, respectively, overpowering the reference compound in the assay (cisplatin). Most compounds also exhibited potent antioxidant activity.

Graphical AbstractThree new flavanes and eight known flavonoids were isolated from the fruits of Livistona chinensis. 1 had significantly antiproliferative effects against HL-60 and CNE-1 with the IC50 of 0.2 ± 0.01 and 1.0 ± 0.1 μM, respectively, overpowering the reference compound in the assay (cisplatin).Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 82, Issue 4, June 2011, Pages 609–614
نویسندگان
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