A new chiratane type triterpenoid from the rhizomes of Drynaria fortunei

Chiratone (1), a rare new chiratane type triterpenoid, together with five known triterpenoids were isolated from the rhizomes of Drynaria fortunei (Kunze) J. Sm. The structure was characterized as 20β-hydroxychiratan-22-one on the basis of extensive 1D and 2D NMR, and MS spectroscopic analyses, and was further confirmed by X-ray crystal diffraction. Primary bioassays showed that compound 1 had significant cytotoxic activity against Hela, PC3 and HepG2 cells, with IC50 of 2.92 μM, 1.08 μM and 2.45 μM, respectively.

A rare new chiratane type triterpenoid, chiratone, with cytotoxic activity was isolated from the rhizomes of Drynaria fortunei.Figure optionsDownload as PowerPoint slide