کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2539108 | 1122165 | 2011 | 5 صفحه PDF | دانلود رایگان |
Two new bakkenolides, valerilactones A (1), and B (2), and two known analogues, bakkenolide-H (3) and bakkenolide-B (4), were isolated from the roots of Valeriana jatamansi. Their structures and relative configurations were elucidated by spectroscopic methods (IR, ESIMS, HRESIMS, 1D and 2D NMR) and by comparison of their NMR data with those of related compounds. Compounds 1, 2, and 3 exhibited potent neuroprotective effects against MPP+-induced neuronal cell death in human dopaminergic neuroblastoma SH-SY5Y cells.
Four bakkenolide-type sesquiterpenes (1–4) were isolated from Valeriana jatamansi. Their structures were elucidated by spectroscopic methods. All the compounds showed neuroprotective effects.Figure optionsDownload as PowerPoint slide
Journal: Fitoterapia - Volume 82, Issue 6, September 2011, Pages 849–853