کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2539245 | 1122169 | 2010 | 5 صفحه PDF | دانلود رایگان |
It is well known that inhibition of prolyl oligopeptidase (POP) is involved in memory-related function. In this study, we observed that rosmarinic acid (RA) inhibits POP activity with an IC50 of 63.7 μM. Subsequently, we investigated the cognitive-enhancing effects of RA employing the Morris water maze paradigm. The results demonstrated that RA is non-competitive POP inhibitor and that acute and subchronic RA treatments showed an inverted U-shaped dose–response curve in the platform crossings. Furthermore, chronic RA treatment significantly increased the platform crossings. These results suggest that RA has a cognitive-enhancing effect which may be mediated by inhibition of POP.
Rosmarinic acid, a natural prolyl oligopeptidase inhibitor, showed cognitive-enhancing effects in the Morris water maze task.Figure optionsDownload as PowerPoint slide
Journal: Fitoterapia - Volume 81, Issue 6, September 2010, Pages 644–648