کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2539306 | 1122171 | 2011 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: New furostanol saponins from Smilax aspera L. and their in vitro cytotoxicity New furostanol saponins from Smilax aspera L. and their in vitro cytotoxicity](/preview/png/2539306.png)
The occurrence of the two new cis-fused A/B rings furostanol saponins (25S)-26-O-β-d-glucopyranosyl-5β-furostan-1β,3β,22α,26-tetraol-1-O-β-d-glucopyranoside and (25S)-26-O-β-d-glucopyranosyl-5β-furostan-1β,2β,3β,5β,22α,26-hexaol and the known compounds (25S)-26-O-β-d-glucopyranosyl-5β-furostan-3β,22α,26-triol-3-O-α-l-rhamnopyranosyl-(1→2)-O-β-d-glucopyranosyl-(1→2)-O-β-d-glucopyranoside and (25S)-26-O-β-d-glucopyranosyl-5β-furostan-3β,22α,26-triol-3-O-β-d-glucopyranosyl-(1→2)-O-β-d-glucopyranoside, trans-resveratrol, (+) catechin and (−) epicatechin in the rhizomes of Smilax aspera is reported. All saponins have been isolated as their 22-OMe derivatives, which were further subjected to extensive spectroscopic analysis. The isolated furostanol saponins were evaluated for cytotoxic activity against human normal amniotic and human lung carcinoma cell lines using neutral red and MTT assays. In vitro experiments showed significant cytotoxicity in a dose dependent manner with IC50 values in the range of 32.98–94.53 µM.
Figure optionsDownload as PowerPoint slideThe occurrence of two new cis-fused A/B rings furostanol saponins and five known compounds in S. aspera is reported. Furostanol saponins were evaluated for their cytotoxicity.
Journal: Fitoterapia - Volume 82, Issue 2, March 2011, Pages 282–287