کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2539343 | 1122173 | 2011 | 6 صفحه PDF | دانلود رایگان |

Ginger roots have been used to treat inflammation and have been reported to inhibit cyclooxygenase (COX). Ultrafiltration liquid chromatography mass spectrometry was used to screen a chloroform partition of a methanol extract of ginger roots for COX-2 ligands, and 10-gingerol, 12-gingerol, 8-shogaol, 10-shogaol, 6-gingerdione, 8-gingerdione, 10-gingerdione, 6-dehydro-10-gingerol, 6-paradol, and 8-paradol bound to the enzyme active site. Purified 10-gingerol, 8-shogaol and 10-shogaol inhibited COX-2 with IC50 values of 32 μM, 17.5 μM and 7.5 μM, respectively. No inhibition of COX-1 was detected. Therefore, 10-gingerol, 8-shogaol and 10-shogaol inhibit COX-2 but not COX-1, which can explain, in part, the anti-inflammatory properties of ginger.
Pulsed ultrafiltration LC-MS–MS incorporating constant neutral loss scanning and selected reaction monitoring to detect gingerol-related compounds was used to screen an extract of ginger roots for inhibitors of cyclooxygenase-2.Figure optionsDownload as PowerPoint slide
Journal: Fitoterapia - Volume 82, Issue 1, January 2011, Pages 38–43