کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2539343 1122173 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale)
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale)
چکیده انگلیسی

Ginger roots have been used to treat inflammation and have been reported to inhibit cyclooxygenase (COX). Ultrafiltration liquid chromatography mass spectrometry was used to screen a chloroform partition of a methanol extract of ginger roots for COX-2 ligands, and 10-gingerol, 12-gingerol, 8-shogaol, 10-shogaol, 6-gingerdione, 8-gingerdione, 10-gingerdione, 6-dehydro-10-gingerol, 6-paradol, and 8-paradol bound to the enzyme active site. Purified 10-gingerol, 8-shogaol and 10-shogaol inhibited COX-2 with IC50 values of 32 μM, 17.5 μM and 7.5 μM, respectively. No inhibition of COX-1 was detected. Therefore, 10-gingerol, 8-shogaol and 10-shogaol inhibit COX-2 but not COX-1, which can explain, in part, the anti-inflammatory properties of ginger.

Pulsed ultrafiltration LC-MS–MS incorporating constant neutral loss scanning and selected reaction monitoring to detect gingerol-related compounds was used to screen an extract of ginger roots for inhibitors of cyclooxygenase-2.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 82, Issue 1, January 2011, Pages 38–43
نویسندگان
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