Antitrypanosomal activity of polycarpol from Piptostigma preussi (Annonaceae)

Polycarpol, sitosterol and sitosterol-3-O-β-D-glucoside isolated for the first time from Piptostigma preussi (Annonaceae) occur regularly in some Annonaceae such as Piptostigma genus. Polycarpol exhibits interesting antitrypanosomal activity with an ED50 value of 5.11 µM on Trypanosoma brucei cells. Moreover, it inhibits T. brucei glycolytic enzymes GAPDH and PFK with IC50 values of 650 and 180 µM respectively.

Compounds 1–3 were isolated for the first time from Piptostigma preussi (Annonaceae). Polycarpol (2) exhibits interesting antitrypanosomal activities on Trypanosoma brucei cells and some of its enzymes.Figure optionsDownload as PowerPoint slide