Keywords: Trypanosoma brucei; Cysteine protease; Natural products; Quinoline;
مقالات ISI (ترجمه نشده)
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Keywords: Trypanosoma brucei; Manganese complexes; Chemotherapy; Drug combination;
Keywords: Antikinetoplastids; Trypanosoma brucei; Leishmania donovani; Polyamines;
Keywords: Trypanosoma brucei; Triazine; Phenotypic screening; Microsomal stability; Cidal efficacy;
Keywords: Trypanosoma brucei; Dimer; Microsomal stability; Phenotypic screening;
Keywords: Pharmacokinetics; Time-kill; Bioluminescence; Fexinidazole; Microdialysis; Trypanosoma brucei;
Keywords: Antiparasite chemotherapy; Ethnopharmacology; Extracts; Leishmania mexicana; Purified compounds; Trypanosoma brucei;
Keywords: Folate pathway; Trypanosomatids; Structure-based drug design; Selective inhibition; Enzyme inhibitor; Anti-parasitic drug; PTR1; Pteridine reductase 1; DHFR; Dihydrofolate reductase; dUMP; Deoxyuridine monophosphate; dTMP; Deoxythymidine monophosphate; hD
Keywords: GK; glycerol kinase; LC-MS/MS; liquid chromatography tandem mass spectrometry; G3P; glycerol 3-phosphate; Pi; inorganic phosphate; Tbg; Trypanosoma brucei gambiense; Tbr; Trypanosoma brucei rhodesiense; pNPP; paranitrophenyl phosphate; WHO; World Health O
Keywords: 5-Nitro-2-aminothiazoles; Type I nitroreductase; Antitrypanosomal agents; Chagas disease; Leishmania; MZSRZQZBRGCXDO-UHFFFAOYSA-N; NTD; Neglected tropical diseases; T. brucei; Trypanosoma brucei; HAT; human African trypanosomiasis; T. cruzi; Trypanosoma
Keywords: Phosphodiesterase; Surface plasmon resonance; Small molecules; Trypanosoma brucei; African sleeping disease;
Keywords: Nitrotriazoles; Type I nitroreductase; Chagas disease; HAT disease; Leishmania; NTD; Neglected tropical diseases; T. brucei; Trypanosoma brucei; HAT; human African trypanosomiasis; T. cruzi; Trypanosoma cruzi; Bnz; benznidazole (N-benzyl-2-(2-nitro-1H-i
Keywords: Trypanosoma brucei; Cysteine protease inhibitors; Anti-sleeping sickness drugs; Drug combination
Keywords: AOI; area of interest; CSF; cerebrospinal fluid; Dpi; day post-infection; HAT; Human African trypanosomiasis; iNOS; inducible nitric oxide synthase; LD; light/dark; LH; lateral hypothalamus; LPS; lipopolysaccharide; MCH; melanin-concentrating hormone; OX;
Keywords: Glutamylation; Polyglutamylases; Microtubules; Leishmania major; Trypanosoma brucei; Tubulin Tyrosine Ligase-Like;
Keywords: Cynaropicrin; Guaianolide; Trypanosoma brucei; SAR; Derivatization;
Keywords: African trypanosomiasis; Trypanosoma brucei; Antitrypanosomal activity; NNRTIs; Triazines;
Keywords: Nitrotriazoles; Nitroimidazoles; Heteroarylamides; Heteroarylsulfonamides; Chagas disease; Antitrypanosomal agents; NTD; neglected tropical diseases; T. cruzi; Trypanosoma cruzi; T. brucei; Trypanosoma brucei; HAT; human African trypanosomiasis; Nfx; ni
Keywords: Anti-trypanosomal activity; Africa; Medicinal plants; Trypanosoma brucei
Keywords: AT1; AQP2; MRPA; drug resistance; MIP; Trypanosoma brucei;
Keywords: Trypanosoma brucei; Mitochondrion; FoF1 ATPase; Succinate dehydrogenase; Phosphonium salt; SDH complex
Depletion of the extracellular-signal regulated kinase 8 homolog in Trypanosoma brucei in vivo reduces its virulence in a mouse target validation study
Keywords: Trypanosoma brucei; in vivo; MAPK; Drug target; DNA; replicationReplication; RNAi;
The pseudo-dimeric tyrosyl-tRNA synthetase of T. brucei aminoacylates cytosolic and mitochondrial tRNATyr and requires both monomeric units for activity
Keywords: Trypanosoma brucei; tRNA; Mitochondria; Aminoacyl-tRNA synthetase;
Substrate specificity profiling of M32 metallocarboxypeptidases from Trypanosoma cruzi and Trypanosoma brucei
Keywords: Abz; ortho-aminobenzoic acid; Dnp; 2, 4-dinitrophenyl; FRET; fluorescence resonance energy transfer; MCP; metallocarboxypeptidase; MOPS; 3-(N- morpholino)propanesulfonic acid; PS-SC; positional scanning synthetic combinatorial; TbMCP-1; Trypanosoma brucei
Identification of tagitinin C from Tithonia diversifolia as antitrypanosomal compound using bioactivity-guided fractionation
Keywords: 1D and 2D NMR; One and two-dimensional nuclear magnetic resonance; BALB//3T3; Mouse fibroblasts; CH2Cl2/MeOH; Methylene chloride/Methanol; DMSO; Dimethylsulfoxide; HAT; Human African Trypanosomiasis; NTDs; Neglected tropical diseases; SAR; Structure-activ
The glycosomal alkyl-dihydroxyacetonephosphate synthase TbADS is essential for the synthesis of ether glycerophospholipids in procyclic trypanosomes
Keywords: Trypanosoma brucei; Null mutant; Alkyl-dihydroxyacetonephosphate synthase; Ether glycerophospholipids; Glycosome; ADS; alkyl-dihydroxyacetonephosphate synthase; DHAP; dihydroxyacetonephosphate; DHAPAT; DHAP acyltransferase; ESI-MS/MS; electrospray ionizat
Trypanosoma brucei bloodstream forms express highly specific and separate transporters for adenine and hypoxanthine; evidence for a new protozoan purine transporter family?
Keywords: Trypanosoma brucei; Nucleobase uptake; Hypoxanthine; Adenine; ENT family;
Identification of highly effective antitrypanosomal compounds in essential oils from the Apiaceae family
Keywords: Apiaceae; Essential oils; Human African trypanosomiasis; Trypanosoma brucei; BALB/3T3;
New heterobimetallic ferrocenyl derivatives: Evaluation of their potential as prospective agents against trypanosomatid parasites and Mycobacterium tuberculosis
Keywords: Ferrocenyl compounds; Tropolone derivatives; Trypanosoma brucei; Mycobacterium tuberculosis; Leishmaniasis;
The conserved hypothetical protein Tb427.10.13790 is required for cytokinesis in Trypanosoma brucei
Keywords: DAPI; 4´, 6-diamidino-2-phenylindole; DIC; differential interference contrast; dsRNA; double-stranded RNA; eGFP; enhanced green fluorescent protein; FAZ; flagellum attachment zone; HAT; human African trypanosomiasis; ORF; open reading frame; qRT-PCR; qua
TbVps15 is required for vesicular transport and cytokinesis in Trypanosoma brucei
Keywords: Trypanosoma brucei; TbVps15 protein kinase; Cell cycle; Endocytosis;
A single-point mutation in the RNA-binding protein 6 generates Trypanosoma brucei metacyclics that are able to progress to bloodstream forms in vitro
Keywords: BARP; brucei alanine-rich protein; BES; bloodstream expression site; BF; bloodstream forms; GO; Gene Ontology; MF; metacyclic forms; mVSG; metacyclic variant surface glycoprotein; Pol I; RNA polymerase I; PF; procyclic forms; RBP6; RNA binding protein 6;
Trypanosoma brucei aquaglyceroporins mediate the transport of metabolic end-products: Methylglyoxal, D-lactate, L-lactate and acetate
Keywords: Aquaglyceroporins; Methylglyoxal; Lactate; Acetate; Trypanosoma brucei;
A plant-like mitochondrial carrier family protein facilitates mitochondrial transport of di- and tricarboxylates in Trypanosoma brucei
Keywords: MCF; mitochondrial carrier family; TCA; tricarboxylic acid cycle; TbMCP; T. brucei MCF protein; CIT; citrate carrier; DIC; dicarboxylate carrier; OGC; oxoglutarate carrier; DTC; di-tricarboxylate carrier; CAT; carboxyatractyloside; ROS; reactive oxygen sp
Shedding light on lipid metabolism in Kinetoplastida: A phylogenetic analysis of phospholipase D protein homologs
Keywords: CLS; cardiolipin synthase; DAG; diacylglycerol; DGK; diacylglycerol kinase; DGPP; diacylglycerol pyrophosphate; GPI; glycosyphosphatidylinositol; MAP kinase; mitogen-activated protein kinase; PA; phosphatidic acid; PC; phosphatidyl choline; PE; phosphatid
Autophagic-related cell death of Trypanosoma brucei induced by bacteriocin AS-48
Keywords: Trypanosoma brucei; Antimicrobial peptides; AS-48; Autophagy; Sleeping sickness; Trypanocidal drugs;
Aryl thiosemicarbazones for the treatment of trypanosomatidic infections
Keywords: Thiosemicarbazone; Trypanosoma brucei; Trypanosoma cruzi; Leishmania infantum; Early-toxicity; pan-anti-trypanosomatidic activity;
Cloning and characterisation of the Equilibrative Nucleoside Transporter family of Trypanosoma cruzi: ultra-high affinity and selectivity to survive in the intracellular niche
Keywords: Trypanosoma cruzi; Equilibrative Nucleoside Transporter; Thymidine transporter; Pyrimidine-specific uptake; Trypanosoma brucei; Heterologous expression;
Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ÎMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense
Keywords: SHAM; Triphenylphosphonium salt (TPP); Quinolinium salt; Lipophilic cation; Trypanosomiasis; Trypanocide; Mitochondrial targeting; Parasite respiration; Trypanosome alternative oxidase (TAO); Trypanosoma brucei; T. b. rhodesiense; T. congolense; AF; asc
Zinc finger nuclease technology: A stable tool for high efficiency transformation in bloodstream form T. brucei
Keywords: HA; haemagglutinin; UTR; untranslated region; ZFN; zinc finger nuclease(s); Trypanosoma brucei; zinc finger nuclease; double-strand break; homologous recombination; transfection efficiency;
NADH dehydrogenase of Trypanosoma brucei is important for efficient acetate production in bloodstream forms
Keywords: Trypanosoma brucei; Mitochondrion; NDH2; Respiratory complex I; NADH:ubiquinone oxidoreductase; Acetate;
Optimization of a binding fragment targeting the “enlarged methionine pocket” leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors
Keywords: Human African trypanosomiasis; Methionyl-tRNA synthetase; Structure-based design; Trypanosoma brucei;
Evaluation of the antiprotozoan properties of 5â²-norcarbocyclic pyrimidine nucleosides
Keywords: Leishmania; Trypanosoma brucei; Carbocyclic nucleoside; Pyrimidine; Uracil;
An overlooked horticultural crop, Smyrnium olusatrum, as a potential source of compounds effective against African trypanosomiasis
Keywords: Apiaceae; Essential oil; Isofuranodiene; Trypanosoma brucei; Wild celery;
Aquaglyceroporins Are the Entry Pathway of Boric Acid in Trypanosoma brucei
Keywords: aquaglyceroporins; boric acid; Trypanosoma brucei; heterologous expression;
Expression, purification, and crystallization of type 1 isocitrate dehydrogenase from Trypanosoma brucei brucei
Keywords: Isocitrate dehydrogenase; Trypanosoma brucei; Glycosome; Coenzyme dependency; Protein solubility; Crystallization;
Novel 1,2-dihydroquinazolin-2-ones: Design, synthesis, and biological evaluation against Trypanosoma brucei
Keywords: Trypanosomiasis; HAT; Trypanosoma brucei; Quinazolinone; Hit-to-lead; African sleeping sickness;
Conversion of procyclic-form Trypanosoma brucei to the bloodstream form by transient expression of RBP10
Keywords: Trypanosoma brucei; RBP10; Procyclic; Differentiation;
The nuclear RNA binding protein RBP33 influences mRNA and spliced leader RNA abundance in Trypanosoma brucei
Keywords: Trypanosoma brucei; RNA binding protein; Super-resolution microscopy; Electrophoretic mobility shift assay;
Synthesis and in vitro antikinetoplastid activity of polyamine-hydroxybenzotriazole conjugates
Keywords: Antikinetoplastids; Trypanosoma brucei; Leishmania donovani; Polyamines; Benzotriazole; Trypanothione reductase;