Optimization of a binding fragment targeting the “enlarged methionine pocket” leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors

Optimization of a binding fragment targeting the “enlarged methionine pocket” leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors

Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 27, Issue 12, 15 June 2017, Pages 2702-2707

Wenlin Huang, Zhongsheng Zhang, Ranae M. Ranade, J. Robert Gillespie, Ximena Barros-Álvarez, Sharon A. Creason, Sayaka Shibata, Christophe L.M.J. Verlinde, Wim G.J. Hol, Frederick S. Buckner, Erkang Fan,