کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2539947 1122200 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hepatoprotection of Phyllanthus maderaspatensis against experimentally induced liver injury in rats
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Hepatoprotection of Phyllanthus maderaspatensis against experimentally induced liver injury in rats
چکیده انگلیسی

The hexane extract of Phyllanthus maderaspatensis (200 and 100 mg/kg) showed significant hepatoprotection on carbon tetrachloride and thioacetamide induced liver damage in rats. The protective effect was evident from serum biochemical parameters and histopathological analysis. Rats treated with P. maderaspatensis remarkably prevented the elevation of serum AST, ALT and LDH and liver lipid peroxides in CCl4 and thioacetamide treated rats. Hepatic glutathione levels significantly increased by the treatment with the extracts. Histopathological changes induced by CCl4 and thioacetamide were also significantly reduced by the extract treatment. The activity of hexane extracts of P. maderaspatensis was comparable to that of silymarin, the reference hepatoprotective drug.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 78, Issue 2, February 2007, Pages 134–141
نویسندگان
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