کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2544774 1560378 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Protective effect of the methanolic leaf extract of Eclipta alba (L.) Hassk. (Asteraceae) against gentamicin-induced nephrotoxicity in Sprague Dawley rats
ترجمه فارسی عنوان
اثر حفاظتی عصاره متانولی برگ Eclipta آلبا (L.) Hassk. (Asteraceae) در برابر سمیت کلیوی ناشی از جنتامایسین موش نژاد Sprague Dawley
کلمات کلیدی
Eclipta alba و نفروتوکسیسیتی ناشی از جنتامایسین ؛ گونه های اکسیژن واکنش پذیر؛ فعالیت های حفاظتی
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
چکیده انگلیسی

Ethnopharmacological relevanceEclipta alba, also known as Eclipta prostrata, is a weed of the family Asteraceae found in tropical and subtropical regions widely used in herbal medicine, including treatment of renal diseases.Aim of the studyThis study aims to evaluate the protective effect of the methanolic leaf extract of Eclipta alba on gentamicin-induced nephrotoxicity in rats.Materials and methodsNephrotoxicity was induced in rats by subcutaneous injection of gentamicin (80 mg/kg/day for seven days). Quercetin was used as a positive control. The nephroprotective activity was evaluated by determining blood urea nitrogen, serum creatinine, urinary microprotein, renal catalase and malondialdehyde levels.ResultsThe extract protected the rat kidneys against gentamicin-induced renal tubular alterations and rises in blood urea nitrogen, serum creatinine, and microprotein levels. Lipid peroxidation and decrement in catalase levels were also ameliorated.ConclusionThe study revealed the protective effect of the methanolic leaf extract of E. alba and suggests that the probable mechanism for the nephroprotection by the extract may be due to its good radical scavenging activity and Fe3+ ion-reducing ability.

Figure optionsDownload high-quality image (262 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 184, 26 May 2016, Pages 18–21
نویسندگان
,