کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2548827 1124473 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Glutamine protects against cisplatin-induced nephrotoxicity by decreasing cisplatin accumulation
ترجمه فارسی عنوان
گلوتامین از طریق کاهش میزان تجمع سیس پلاتین در برابر نفوذ سمیت ناشی از سیس پلاتین محافظت می کند
کلمات کلیدی
سیس پلاتین، نفوذپذیری، گلوتامین، آسیب حاد کلیه، جذب سیس پلاتین
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
چکیده انگلیسی

Cisplatin is a chemotherapeutic drug but induces acute kidney injury (AKI). Cisplatin-induced AKI depends on several signaling pathways leading to apoptosis in tubular epithelial cells. Glutamine is a substrate for the synthesis of glutathione, the most abundant intracellular thiol and antioxidant, and plays an important role in protecting cells from apoptosis induced by different stimuli. In the present study, we investigated the protective effect of glutamine on cisplatin-induced AKI. Rats were divided into control, glutamine, cisplatin, and cisplatin plus glutamine groups. Glutamine ameliorated renal dysfunction, tissue injury, and cisplatin-induced apoptosis. Cisplatin increased cell death, caspase-3 cleavage, activation of MAPKs and p53, oxidative stress, and mRNA expression of TNF-α and TNFR1 in HK-2 cells. Glutamine treatment reduced cisplatin-induced these changes in HK-2 cells. Notably, glutamine reduced the cisplatin-induced expression of organic cation transporter 2 (OCT2) and cisplatin accumulation. Our results suggest that the protective effect of glutamine on cisplatin is specific for proximal tubular cells and the initial effects may be related to attenuation of cisplatin uptake. Thus, glutamine administration might represent a new strategy for the treatment of cisplatin-induced AKI.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmacological Sciences - Volume 127, Issue 1, January 2015, Pages 117–126
نویسندگان
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