کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2568118 1561163 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The concept of bio-corona in modulating the toxicity of engineered nanomaterials (ENM)
ترجمه فارسی عنوان
مفهوم زیستی کرونا در تعدیل سمیت نانومواد مهندسی شده (ENM)
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


• “Nanotoxicology” has emerged an autonomous field with an explosive growth.
• Nanomaterials adsorb (bio)molecules forming the so-called (bio)molecule corona.
• (Fine-)tune of the corona composition could enable new possibilities in nanomedicine.

Besides the wide use of engineered nanomaterials (ENM) in technical products, their application spectrum in biotechnology and biomedicine is steadily increasing. In complex physiological environments the physico-chemical properties and the behavior of nanoparticles (NPs) are challenging to characterize. Biomolecules rapidly adsorb to the nanomaterial, leading to the formation of the protein/biomolecule corona, which critically affects the nanomaterials' (patho)biological and technical identities. This formation can trigger an immune response and affect nanoparticles' toxicity and targeting capabilities. In this review, we provide a survey of recent findings on the (protein)corona-nanoparticle interaction and discuss how the corona modulates both cytotoxicity and the immune response as well as to improve the efficacy of targeted delivery of nanocarriers.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology and Applied Pharmacology - Volume 299, 15 May 2016, Pages 53–57
نویسندگان
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