کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2576173 1561348 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Proposed interaction of some novel antidepressant pyrazolines against monoamine oxidase isoforms. Molecular docking studies and PASS assisted in silico approach
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی طب سالمندان و علم پیری شناسی
پیش نمایش صفحه اول مقاله
Proposed interaction of some novel antidepressant pyrazolines against monoamine oxidase isoforms. Molecular docking studies and PASS assisted in silico approach
چکیده انگلیسی

The validity of pyrazoline heterocyclic core for the design of inhibitors of monoamine oxidase has been previously established. Recently our group synthesized some novel thiophene based pyrazoline-carbothioamides and found good antidepressant activity. The objective of the current study is to identify the reason for such biological activities of the molecules by using molecular docking studies. In the molecular modeling studies, it is revealed that most of the antidepressant molecules showed good binding affinity towards MAO-A than MAO-B that is an effective target for the treatment of depression.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Aging Pathology - Volume 4, Issue 4, October–December 2014, Pages 297–301
نویسندگان
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