کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2576186 | 1129852 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Camel urine inhibits inflammatory angiogenesis in murine sponge implant angiogenesis model
ترجمه فارسی عنوان
ادرار شتر را مهار آنژیوژنز التهابی را در مدل آنژیوژنز ایمپلنت اسفنجی مهار می کند
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
طب سالمندان و علم پیری شناسی
چکیده انگلیسی
Camel urine has traditionally been used to treat cancer, but this practice awaits scientific scrutiny, in particular its role in tumor angiogenesis, the key step involved in tumor growth and metastasis. We aimed to investigate the effects of camel urine on key components of inflammatory angiogenesis in the murine cannulated sponge implant angiogenesis model. Polyester-polyurethane sponges, used as a framework for fibrovascular tissue growth, were implanted in Swiss albino mice and camel urine (25, 50 and 100 mg/kg/day) was administered for 14 days through installed cannula. The implants, collected at day 14 post-implantation, were processed for the assessment of hemoglobin (Hb), myeloperoxidase (MPO), N-acetylglucosaminidase (NAG) and collagen, which were used as indices for angiogenesis, neutrophil and macrophage accumulation and extracellular matrix deposition, respectively. Relevant inï¬ammatory, angiogenic and ï¬brogenic cytokines were also determined. Camel urine treatment attenuated the main components of the ï¬brovascular tissue, wet weight, vascularization (Hb content), macrophage recruitment (NAG activity), collagen deposition and the levels of vascular endothelial growth factor (VEGF), interleukin (IL)-1β, IL-6, IL-17, tumor necrosis factor (TNF)-α and transforming growth factor (TGF-β). A regulatory function of camel urine on multiple parameters of the main components of inflammatory angiogenesis has been revealed giving insight into the potential therapeutic benefit underlying the anti-cancer actions of camel urine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Aging Pathology - Volume 4, Issue 1, JanuaryâMarch 2014, Pages 9-16
Journal: Biomedicine & Aging Pathology - Volume 4, Issue 1, JanuaryâMarch 2014, Pages 9-16
نویسندگان
Abdulqader A. Alhaider, Abdel Galil M. Abdel Gader, Nawaf Almeshal, Sarita Saraswati,