Chemotherapeutic efficacy of limonin against Aflatoxin B1 induced primary hepatocarcinogenesis in Wistar albino rats

Hepatocellular carcinoma (HCC) is one of the most common life-threatening cancers in the world. This cancer generally arises within the boundaries of well-defined fundamental factors. In this investigation, the defensive role of limonin on detoxification system in Aflatoxin B1 induced hepatocellular carcinoma, which is a necessary mechanism in cancer treatment, was studied in experimental rats. After 45 days, the treatment of limonin (50 mg kg bw; p.o) for 28 successive days to Aflatoxin B1 (2 mg kg bodyweight; ip) induced liver cancer bearing rats is found to be highly effective in reducing Alpha-fetoprotein level, LPO levels and enhancing both phase I and phase II enzymes to near normal levels. From this investigation, we concluded that the limonin has strong anticancer activity against Aflatoxin B1-induced hepatocarcinogenesis, is mediated through the induction of xenobiotic enzymes and histopathological analysis.