Effect of Terminalia chebula fruit extract on ethylene glycol induced urolithiasis in rats

AimThe present study was undertaken to investigate antiurolithiatic property of aqueous extract of fruit of Terminalia chebula in Wistar albino rats.Materials and methodsThe protective effect of aqueous extract of Terminalia chebula fruit was evaluated at two dose levels (100 and 200 mg/kg body weight) using ethylene glycol induced calcium oxalate urolithiasis model in rats.ResultsThe results indicate that ethylene glycol treatment decreases calcium level in urine and increased that in the kidney tissue homogenate, which were prevented in animal receiving simultaneous treatment of extract. Extract treatment decreased the elevated levels of oxalate and phosphate in urine as well as kidney tissue homogenate. The extract supplementation also prevented the elevation of serum levels creatinine, uric acid and blood urea nitrogen. Histopathological study revealed that extract reduced histological changes and retained the normal architecture of kidney tissue.ConclusionThis finding indicates that aqueous extract of Terminalia chebula fruit possessed antiurolithiatic activity.