کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2576370 1561353 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of tryptophan cation–pi interactions on ammonia transport through the AmtB ammonia channel
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
The role of tryptophan cation–pi interactions on ammonia transport through the AmtB ammonia channel
چکیده انگلیسی

.The high-resolution structure of Escherichia coli AmtB ammonia/ammonium channel and proteoliposome functional analysis has provided sufficient information to propose a permeation theory for this integral membrane channel protein. The role of cation–pi interactions at the periplasmic vestibule of the channel is proposed and integrated with molecular and quantum mechanical dynamics simulations and calculations. The structural and simulation data closely reinforce each other and point to cation–pi interactions as one of the primary mechanisms of ligand recruitment within the channel vestibule.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Congress Series - Volume 1304, 1 November 2007, Pages 15–21
نویسندگان
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