کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2577441 | 1561368 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The structure of the cell-wall protease from streptococci that inactivates the human complement factor 5a
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The structure of the cell-wall protease from streptococci that inactivates the human complement factor 5a The structure of the cell-wall protease from streptococci that inactivates the human complement factor 5a](/preview/png/2577441.png)
چکیده انگلیسی
The structure of a 949-residue fragment of complement factor 5a peptidase (SCP) was determined to 1.9 Å resolution. The molecule is made of five distinct domains in an elongated head–stalk structure. The structure suggests that activity of SCP can be modulated through binding of integrins to 2 RGD sequences. This structure is the first of an enzyme that is covalently attached to the cell wall of a Gram-positive bacteria. SCP is also the first functional protease containing a protease-associated domain to have its structure elucidated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Congress Series - Volume 1289, April 2006, Pages 211–215
Journal: International Congress Series - Volume 1289, April 2006, Pages 211–215
نویسندگان
C. Kent Brown, Zu-Yi Gu, Yury V. Matsuka, Stephen B. Olmsted, P. Patrick Cleary, Douglas H. Ohlendorf, Cathleeen A. Earhart,