کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2582793 1561700 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effect of occupational exposure on pro/antioxidant balance in the blood of non-smoking and smoking smelters with diabetes
ترجمه فارسی عنوان
اثر مواجهه شغلی با تعادل پروتئین / آنتی اکسیدانی در خون افراد غیر سیگاری و سیگار کشیدن با دیابت
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


• GTT activity and Pb concentration are mainly increased due to heavy metal toxicity.
• Occupational exposure disorders GSH concentration and GSH-dependent enzymes activities.
• MT concentration is increased due to diabetes, exposure to heavy metals and tobacco smoke.
• Higher MT concentration and lower SOD activity can complement each other under stress conditions.

Arsenic, lead and cadmium, potent environmental toxicants have been reported to induce diabetes mellitus, but their potential biological mechanism(s) have not been much investigated. The present study was designed to correlate parameters of pro/antioxidant balance with occupational exposure on heavy metals and smoking in smelters with diabetes compared on control group.The results showed a significant increase in the concentration of arsenic, cadmium and lead in the blood and urine of smelters, while smoking caused a further increase in the concentration of these metals. Increasing γ-glutamyltransferase activity and lead concentration due to occupational exposure in copper foundry, tobacco smoke and co-existing diabetes were observed. Also these factors have synergistic effects on metallothionein and glutathione concentrations as well as glutathione dependent enzymes activities.Our data suggests that sub-chronic arsenic, lead and cadmium exposure induces diabetic condition which may be mediated due to increased oxidative stress in blood.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 44, June 2016, Pages 99–106
نویسندگان
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