Attenuation of arsenic retention by resveratrol in lung of arsenic trioxide-exposed rats

Arsenic trioxide (As2O3) is an important environmental toxin. In this study, the effect of resveratrol on As2O3-induced lung injury in rats is evaluated. The results showed that pre-treatment with resveratrol protected As2O3-induced lung injury by the maintenance of glutathione redox system and decrease in arsenic retention. These suggest supplement with resveratrol may alleviate lung injury in the individuals with chronic exposure to arsenic.

► Resveratrol attenuates As2O3-induced lung injury.
► Resveratrol decreases As2O3-induced redox imbalance in lung.
► Resveratrol decreases arsenic retention in lung.
► Resveratrol decreases arsenic toxicity.