کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2583138 | 1130680 | 2015 | 10 صفحه PDF | دانلود رایگان |
• C. carpio showed the most sensitive CYP1A induction in four species for BaP exposure.
• Gill was more sensitive and useful in assessing BaP risk than liver.
• CYP1A transcript level revealed significant interspecies difference.
• The difference of dose–response curve slope was found in four species.
• Significant translational efficiency was not observed in four species.
Oryzias latipes, Danio rerio, Cyprinus carpio, and Zacco platypus are useful indicator species for CYP1A biomarker studies; however, comparative studies have not been performed. To compare susceptibility, dose- and time-dependent CYP1A induction at the mRNA and protein levels in response to benzo(a)pyrene (BaP) exposure was analyzed. At the mRNA level, a statistically significant difference was found among the four species; however, such was not observed at the protein level. C. carpio showed the highest CYP1A induction level and the steepest slope in the dose–response curve. To assess susceptibility, the difference in CYP1A mRNA induction among species must be considered, and C. carpio was the most sensitive species of the four evaluated in terms of CYP1A expression.
Journal: Environmental Toxicology and Pharmacology - Volume 39, Issue 3, May 2015, Pages 1041–1050