The impaired disposition of probe drugs is due to both liver and kidney dysfunctions in CCl4-model rats

► The impaired disposition of probe drugs is due to both liver and kidney dysfunctions in CCl4-model rats. ► We examine the effect of CCl4 on the mRNA expression and activity of SULT1A1 and UGT1A6. ► We examine the effect of CCl4 on the pharmacokinetics of phenacetin and acetaminophen.