کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2583262 1130685 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Exposure to a low dose of bisphenol A impairs pituitary-ovarian axis in prepubertal rats: Effects on early folliculogenesis
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Exposure to a low dose of bisphenol A impairs pituitary-ovarian axis in prepubertal rats: Effects on early folliculogenesis
چکیده انگلیسی


• We studied BPA effect on the reproductive axis of prepubertal female rats.
• Early exposure to a low dose of BPA disrupts female reproductive axis function.
• Early exposure to BPA alters the folliculogenesis in prepubertal female rats.

The research work studies the effect of providing a low dose of bisphenol A (BPA), on the reproductive axis of prepubertal female rats. Wistar mated rats were treated with either 0.1% ethanol or BPA in their drinking water until their offspring were weaned on the 21 day of birth. The estimated average dose of exposure to dams was approximately 3 μg/kg/day. The pups were sacrificed at the 30th day of life. Body weight at the moment of the sacrifice was significantly higher in the group exposed to BPA; ovarian weight and its relative weight were not modified. LH and estradiol levels increased significantly, meanwhile FSH ones showed no significant changes. The number of primary, secondary and atretic follicles increased and antral ones was decreased. Our results demonstrated that early exposure to a low dose of BPA disrupts the normal function of the reproductive axis in prepubertal female rats.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 39, Issue 1, January 2015, Pages 9–15
نویسندگان
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