کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2583343 | 1130687 | 2011 | 12 صفحه PDF | دانلود رایگان |
Bisphenol A (BPA) is a widespread endocrine disrupting chemical that influences adult physiology and behavior after perinatal exposure. However, it is not clear if pubertal exposure to BPA exerts hormone dependent effects on behaviors. Using C57BL/6J mice, we sought to determine how pubertal exposure to BPA affects locomotion, exploration, anxiety and sociability in adulthood. Compared to controls, pubertal exposure to BPA or E2 (17β-estradiol) significantly altered female exploratory and anxiety behavior. Moreover, BPA and E2-treated female mice displayed increased levels of affiliation to female stimulus mice and decreased levels of affiliation to male stimulus mice; while our control males showed affiliation preference to female stimulus. These results indicate that pubertal exposure to BPA or E2 may masculinize female social and emotional behavior.
Journal: Environmental Toxicology and Pharmacology - Volume 31, Issue 1, January 2011, Pages 88–99