کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2583483 1130691 2012 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Involvement of STAT3, NF-κB and associated downstream molecules before and after the onset of urethane induced lung tumors in mouse
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Involvement of STAT3, NF-κB and associated downstream molecules before and after the onset of urethane induced lung tumors in mouse
چکیده انگلیسی

Here we have shown the alteration of transcription factors STAT3, NF-κB and downstream associated molecules much before the appearance of lung tumor and their response to antitumor agent, inositol hexaphosphate. Histological examination revealed the pathophysiology of the lung tissues and the onset or progression of tumor from 4 or 9 to 24 weeks in terms of tumor volume and the number. Over expression of NF-κB (p50/Rel A), COX-2, STAT3, pSTAT3 (Tyr 705), IL-6 and cyclin D1 also progressed from the time of no tumor to the time of tumor appearance and was reduced in mice drinking 2%IP6. We suggest that the alterations of STAT3, NF-κB and downstream associated molecules are critical in the development of lung tumors and can be exploited as possible mechanisms after the exposure. Status of these altered genes before the tumor development suggests their possible use as targets for the tumor control in the predisposed conditions.


► Study of urethane exposed mouse lungs before and after the onset of tumors.
► Involvement STAT3, NF-κB, COX-2, cyclin D1, IL-6.
► Protection of tumor development and the restoration of molecular changes by IP6.
► Suggesting the prospective targets for the tumor control even before the onset of tumor in predisposed conditions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 34, Issue 2, September 2012, Pages 502–511
نویسندگان
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