کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2583583 1130695 2012 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Gene expression profiling of nephrotoxicity from copper nanoparticles in rats after repeated oral administration
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Gene expression profiling of nephrotoxicity from copper nanoparticles in rats after repeated oral administration
چکیده انگلیسی

The goal of this study was to investigate the mechanisms of nanocopper-induced nephrotoxicity by analyzing renal gene expression profiles phenotypically anchored to conventional toxicological outcomes. Male Wistar rats were given nanocopper (50, 100, 200 mg/kg) and microcopper (200 mg/kg) at different doses for 5 days. We found nanocopper can induce widespread renal proximal tubule necrosis in rat kidneys with blood urea nitrogen and creatinine increase. Whole genome transcriptome profiling of rat kidneys revealed significant alterations in the expression of many genes involved in valine, leucine, and isoleucine degradation, complement and coagulation cascades, oxidative phosphorylation, cell cycle, mitogen-activated protein kinase signaling pathway, glutathione metabolism, and others may be involved in the development of these phenotypes. Results from this study provide new insights into the nephrotoxicity of copper nano-particles and illustrate how toxicogenomic approaches are providing an unprecedented amount of mechanistic information on molecular responses to nanocopper and how they are likely to impact hazard and risk assessment.


► Nanocopper compared to microcopper can induce nephrotoxicity of rats.
► A few genes dramatically changed in the rat are related to the nephrotoxicity.
► Systems toxicology used in nanotoxicology seems yielding valuable insight.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 34, Issue 1, July 2012, Pages 67–80
نویسندگان
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