کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2583594 1130696 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Involvement of oxidative stress in the mechanism of cadmium-induced toxicity on rat uterus
ترجمه فارسی عنوان
مشارکت استرس اکسیداتیو در مکانیسم سمیت ناشی از کادمیم در رحم موش صحرایی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


• Cd accumulates in a dose-dependent manner in uterus after oral administration.
• Cadmium changes the activity of catalase and MDA concentration in rat uterus.
• Deposition of Cd in rat uterus generates oxidative stress and lipid peroxidation.

The study was undertaken to explore whether cadmium bioaccumulation can induce oxidative stress in the uterus of rats. Cadmium (0.09, 0.9, 1.8 or 4.5 mgCd/kg b.w.) was administered by gavage for 28 days. The animals were dissected on the first day and then after 90 days post exposure (second group of animals). The results show that cadmium accumulates in the uterus in a dose-dependent manner. The uterine Cd concentrations were almost the same in both groups, which is indicative of its long half-life in this organ. The accumulated cadmium caused significant changes in catalase (CAT) activity and lipid peroxidation (MDA) levels at concentrations from 0.09 to 0.35 μgCd/g wet uterine tissue. In summary our results show that the induction of oxidative stress and lipid peroxidation in the uterus may play important roles in the mechanism of toxicity in this organ and may have a negative impact on reproductive processes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 38, Issue 2, September 2014, Pages 364–373
نویسندگان
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