کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2583619 | 1130696 | 2014 | 9 صفحه PDF | دانلود رایگان |
• This study was designed to assess in vitro and in vivo protective effect of octaphlorethol A.
• Protective effect against at the high glucose-induced cell and zebrafish model.
• Octaphlorethol A possesses a protective effect against high glucose induced oxidative stress.
We investigated the protective effect of octaphlorethol A (OPA) isolated from Ishige foliacea against high-glucose-induced oxidative damage, as indicated by reactive oxygen species (ROS) generation, lipid peroxidation, and cell death, in human umbilical vein endothelial cells (HUVECs) and in a zebrafish model. OPA treatment significantly and dose-dependently decreased ROS generation, lipid peroxidation, and cell death in HUVECs and in a zebrafish model. Our results show that OPA can protect HUVECs and zebrafish against high glucose by suppressing intracellular ROS generation, lipid peroxidation, and cell death.
Journal: Environmental Toxicology and Pharmacology - Volume 38, Issue 2, September 2014, Pages 607–615