کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2583790 | 1130703 | 2011 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The protective effect of C-phycocyanin on paraquat-induced acute lung injury in rats The protective effect of C-phycocyanin on paraquat-induced acute lung injury in rats](/preview/png/2583790.png)
To investigate the potential protective effect of C-phycocyanin (PC) on paraquat (PQ)-induced acute lung injury, rats were divided into control, PQ-treated and PQ + PC-treated groups. Rats in PQ-treated group were orally administered with 50 mg/kg PQ, and rats in PQ + PC-treated group were intraperitoneally injected with 50 mg/kg PC after administration of PQ. At 8, 24, 48 and 72 h after treatments, GSH-Px and SOD activities, MDA levels in plasma and BALF, HYP, NF-κB, IκB-α and TNF-α contents in lung tissues were measured. The pathological changes in lung were observed. After treatment with PC, the levels of MDA and the relative contents of NF-κB and TNF-α were significantly decreased, the activities of GSH-Px and SOD and the relative contents of IκB-α were significantly increased. The degree of rat lung damage was obviously reduced in PQ + PC-treated group. The results suggested that PC treatment significantly attenuated PQ-induced acute lung injury.
► The lung is a major target organ in paraquat poisoning.
► The mechanism for paraquat toxicity involves oxidative stress and inflammation.
► C-phycocyanin possesses antioxidant, radical-scavenging, anti-inflammatory effects.
► C-phycocyanin significantly attenuates PQ-induced acute lung injury in rats.
Journal: Environmental Toxicology and Pharmacology - Volume 32, Issue 2, September 2011, Pages 168–174