کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2583795 | 1130703 | 2011 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The toxicity potential of pharmaceuticals found in the Douro River estuary (Portugal)-Experimental assessment using a zebrafish embryo test
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
⺠The toxicity potential of two mixtures of pharmaceuticals was evaluated using a zebrafish embryo test. ⺠One of the mixtures corresponds to an environmentally realistic scenario and both have carbamazepine, fenofibric acid, propranolol, trimethoprim and sulfamethoxazole. ⺠Results evidenced morphological alterations, such as spinal deformities and yolk-sac oedemas. Moreover, heart rate decreased after both mixture exposures, and the tail lengths also diminished. Toxicological effects were concentration dependent. ⺠Mortality, hatching rate and the number of spontaneous movements were not affected. ⺠The low levels of pharmaceuticals did interfere with the normal development of zebrafish, which suggests risks for wild organisms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 32, Issue 2, September 2011, Pages 212-217
Journal: Environmental Toxicology and Pharmacology - Volume 32, Issue 2, September 2011, Pages 212-217
نویسندگان
Tânia Vieira Madureira, Catarina Cruzeiro, Maria João Rocha, Eduardo Rocha,