کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2584332 | 1130730 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Induced gene expression in oyster Crassostrea gigas exposed to sewage
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
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چکیده انگلیسی
Pacific oysters, Crassostrea gigas, were exposed to untreated sewage diluted in seawater. After 48 h of exposure, the expression of genes associated to biotransformation pathways (CYP356A1, GSTO, MDR, FABP and ALAS) were analyzed in gills through semi-quantitative RT-PCR. A significant induction in all genes analyzed in the sewage-exposed oysters was observed. These genes are related to phase I (CYP356A1), phase II (GSTO) and phase III (MDR) biotransformation systems, to the uptake and transport of hydrophobic ligands (FABP) and to the synthesis of prosthetic group heme (ALAS). The organisms were able to survive in contaminated conditions since protective mechanisms have been properly stimulated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 26, Issue 3, November 2008, Pages 362–365
Journal: Environmental Toxicology and Pharmacology - Volume 26, Issue 3, November 2008, Pages 362–365
نویسندگان
Igor D. Medeiros, Marília N. Siebert, Guilherme Toledo-Silva, Thiago B. Rodrigues, Maria R.F. Marques, Afonso C.D. Bainy,