کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2584430 1130737 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Formaldehyde adduct to human serum albumin with reference to aspartame intake
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Formaldehyde adduct to human serum albumin with reference to aspartame intake
چکیده انگلیسی

A preliminary study was performed to evaluate the role of formaldehyde (F) deriving from aspartame intake in the production of the adduct F-human serum albumin (F-HSA) by mean of a sera-epidemiological investigation. A blood-donors population (68 subjects) was analysed for the presence of anti-F-HSA IgG by an indirect competitive immunoenzymatic assay (displacement assay).Only the 41% of the subjects were aspartame consumer and with a low daily intake (0.96 mg/(kg day)). A 50% sera-prevalence of IgG anti-F-HSA was observed in the population, but no association between this biomarker and aspartame intake was pointed out. A significant association was found between the IgG anti-F-HSA presence and exogenous F exposure sources (cigarette active smoke and occupational exposure).Considering the low number of the investigated subjects and the low doses of aspartame consumption, the results of this preliminary study seems to suggest that aspartame low intake does not influence the formation of F adducts.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 25, Issue 1, January 2008, Pages 89–93
نویسندگان
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