Imidacloprid does not induce Cyp genes involved in insecticide resistance of a mutant Drosophila melanogaster line

• We have analyzed the induction potential of Imidacloprid, widely used neonicotinoid insecticide.
• We have used mutant Drosophila melanogasterline MiT[W−]3R2 resistant to Imidacloprid and DDT as model system.
• Genes Cyp6g1 and Cyp6a2, involved in Imidacloprid resistance, were analyzed for induction.
• We find that Imidacloprid does not induce expression of the analyzed genes.

Certain xenobiotics have the capacity to induce the expression of genes involved in various biological phenomena, including insecticide resistance. The induction potential of different chemicals, among them different insecticides, has been documented for a number of insect species. In this study, we have analyzed the induction potential of Imidacloprid, a widely used member of the neonicotinoid insecticide family. Genes Cyp6g1 and Cyp6a2, known to be involved in the resistance of mutant Drosophila melanogaster line MiT[W−]3R2 to Imidacloprid and DDT were included in the analyzed sample. We find that Imidacloprid does not induce expression of the analyzed genes.

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