کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2585168 | 1561783 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Oxidative stress and myocardial dysfunction in young rabbits after short term anabolic steroids administration
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The present study focuses on the short term effects of repeated low level administration of turinabol and methanabol on cardiac function in young rabbits (4Â months-old). The experimental scheme consisted of two oral administration periods, lasting 1Â month each, interrupted by 1-month wash-out period. Serial echocardiographic evaluation at the end of all three experimental periods was performed in all animals. Oxidative stress markers have also been monitored at the end of each administration period. Treated animals originally showed significantly increased myocardial mass and systolic cardiac output, which normalized at the end of the wash out period. Re-administration led to increased cardiac output, at the cost though of a progressive myocardial mass reduction. A dose-dependent trend towards impaired longitudinal systolic, diastolic and global myocardial function was also observed. The adverse effects were more pronounced in the methanabol group. For both anabolic steroids studied, the low dose had no significant effects on oxidative stress markers monitored, while the high dose created a hostile oxidative environment. In conclusion, anabolic administration has been found to create a possible deleterious long term effect on the growth of the immature heart and should be strongly discouraged especially in young human subjects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 61, November 2013, Pages 101-105
Journal: Food and Chemical Toxicology - Volume 61, November 2013, Pages 101-105
نویسندگان
Ioannis Germanakis, Konstantinos Tsarouhas, Persefoni Fragkiadaki, Christina Tsitsimpikou, Nikolaos Goutzourelas, Maria Christakis Champsas, Demetrios Stagos, Elias Rentoukas, Aristidis M. Tsatsakis,